反应详情

Thereafter, to 150 ml of trimethylamine were added 7.89 g of 2-iodofluorene, 379 mg (0.54 mmol) of bis[triphenylphosphine]palladium dichloride and 51 mg (0.27 mmol) of copper iodide. 4.2 ml (29.7 mmol) of trimethylsilylacetylene was added slowly to the reaction mixture. After the reaction was stirred for 8 h at room temperature, solvent was removed under reduced pressure. The residue was extracted with benzene and the benzene layer was washed with distilled water. The washed benzene layer was concentrated to give 6.02 g (85%) of 2-trimethylsilylethynyl fluorene.

1. customsolvent was removed under reduced pressure
2. extractionThe residue was extracted with benzene
3. washthe benzene layer was washed with distilled water
4. concentrationThe washed benzene layer was concentrated