1-Bromo-2-Chloroethane → Methyl 2-(2-chloroethoxy)-4-methoxybenzoate

HRID 1840956Notes

Reaction equation

HRID 1840956 reaction equation
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[C:8](C)[CH:7]=[CH:6][C:5]=1[OH:11].Br[CH2:14][CH2:15][Cl:16].[C:17](=O)([O-])[O-:18].[K+].[K+]>>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([O:18][CH3:17])=[CH:6][C:5]=1[O:11][CH2:14][CH2:15][Cl:16]

Participants

4

Reactant 3

HCID 78491-Bromo-2-ChloroethaneHCID 11430Potassium CarbonateHCID 89802Methyl 5-methylsalicylate

Product 1

HCID 14087529Methyl 2-(2-chloroethoxy)-4-methoxybenzoate

Procedure

This compound was prepared following the procedure described in Example 1 (part C) starting with 5 g (27.4 mmol) of 2-hydroxy-5-methyl-benzoic acid methyl ester, 9 mL (60.3 mmol) of 1-bromo-2-chloro-ethane and 5.9 g (42.8 mmol) of potassium carbonate. After the work-up and purification, 6.6 g (99% of yield) of the desired product was obtained.

Workup

  1. customThis compound was prepared
  2. customAfter the work-up and purification, 6.6 g (99% of yield) of the desired product
  3. customwas obtained

Sources & evidence

ORD record
ord-b4a29558f24747f9952ab804f61209f1
Source dataset
uspto-grants-2004_01
Patent number
US06683096B2

Reaction notes

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