lithium aluminium hydride THF → [4-(3,4-Dichlorophenyl)-2-pyridinyl]methanol

HRID 1841231Notes

Reaction equation

HRID 1841231 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[C:13]([Cl:18])[CH:12]=2)[CH:8]=[CH:7][N:6]=1)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].C1COCC1>C1COCC1>[Cl:18][C:13]1[CH:12]=[C:11]([C:9]2[CH:8]=[CH:7][N:6]=[C:5]([CH2:3][OH:2])[CH:10]=2)[CH:16]=[CH:15][C:14]=1[Cl:17]

Participants

4

Reactant 2

HCID 68718528lithium aluminium hydride THFHCID 690389284-(3,4-Dichloro-phenyl)-pyridine-2-carboxylic acid methyl ester

Product 1

HCID 23445021[4-(3,4-Dichlorophenyl)-2-pyridinyl]methanol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound, MS: m/e=252.0 ([M−H]−) was obtained as a light brown oil (94% yield) by the reaction of 4-(3,4-dichloro-phenyl)-pyridine-2-carboxylic acid methyl ester with 1M lithium aluminum hydride/THF solution in THF at 20° C. for 1 h followed by chromatographic purification.

Sources & evidence

ORD record
ord-b309bc0be4c84e2abb550bfa712706bc
Source dataset
uspto-grants-2004_01
Patent number
US06683097B2

Reaction notes

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