Methyl iodide → HCID 178470469, compound

HRID 1841440Notes

Reaction equation

HRID 1841440 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:11]=[N:10][C:9]([SH:12])=[N:8][C:7]=1[OH:13])=[O:5])[CH3:2].[C:14](=O)([O-])[O-].[K+].[K+].CI>CN(C=O)C>[CH2:1]([O:3][C:4]([C:6]1[N:11]=[N:10][C:9]([S:12][CH3:14])=[N:8][C:7]=1[OH:13])=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178470471HCID 178470471, compound

Product 1

HCID 178470469HCID 178470469, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a 0° C. solution of 29.0 g (144.1 mmol) of 5-hydroxy-3-mercapto-1,2,4-triazine-6-carboxylic acid ethyl ester in 75 mL of DMF was added 14.4 g (144.1 mmol) of potassium carbonate. The reaction mixture was stirred for 1 hour, and 24.2 mL (389.2 mmol) of methyl iodide was added as fast as the effervescence would allow. The ice bath was removed, and the reaction was covered with a nitrogen filled balloon and stirred at room temperature overnight.

Workup

  1. customThe ice bath was removed
  2. stirringstirred at room temperature overnight

Sources & evidence

ORD record
ord-b6c6e6c5970c4ca9aab1df901edcd437
Source dataset
uspto-grants-2004_01
Patent number
US06683183B2

Reaction notes

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