Propylamine → HCID 69883422, compound

HRID 1841635Notes

Reaction equation

HRID 1841635 reaction equation
[CH2:1]([NH2:4])[CH2:2][CH3:3].[Cl:5][C:6]1[C:11]([N:12]2[C:21](=[O:22])[C:20]3[C:15](=[N:16][C:17]([CH3:23])=[CH:18][CH:19]=3)[C:13]2=[O:14])=[C:10]([C:24]#[N:25])[C:9]([CH3:26])=[CH:8][CH:7]=1>O1CCCC1>[CH2:1]([NH:4][C:13]([C:15]1[C:20]([C:21]([NH:12][C:11]2[C:6]([Cl:5])=[CH:7][CH:8]=[C:9]([CH3:26])[C:10]=2[C:24]#[N:25])=[O:22])=[CH:19][CH:18]=[C:17]([CH3:23])[N:16]=1)=[O:14])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 7852PropylamineHCID 23446882HCID 23446882, compound

Product 1

HCID 69883422HCID 69883422, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.46 g (7.699 mmol) of n-propylamine was added with stirring at 22° C. to a mixture of 0.6 g (1.92 mmol) of the compound from example 11 in 30 ml of tetrahydrofuran and stirred for 12 h. The reaction mixture was concentrated in vacuo and the residue was stirred with diisopropyl ether/diethyl ether 20:1. After filtering off with suction and drying, 0.6 g (82.4% of theory) of the title compound were obtained as colorless crystals of m.p. 129-131° C.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. stirringthe residue was stirred with diisopropyl ether/diethyl ether 20:1
  3. filtrationAfter filtering off with suction
  4. customdrying

Sources & evidence

ORD record
ord-4d7943ea20104657929f74434442f335
Source dataset
uspto-grants-2004_01
Patent number
US06683213B1

Reaction notes

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