2-Bromopropane → HCID 178505971, compound

Air inside a reaction vessel of the same kind as the one used in Example 13 is displaced by a nitrogen gas in a satisfactory manner. Then, 2.040 g (0.084 mole) of magnesium, 13.577 g (0.081 mole) of pentafluorobenzene, and 20 ml of diethyl ether are charged to the reaction vessel. Also, 10.518 g (0.081 mole) of isopropyl bromide is charged to the dropping funnel. Next, isopropyl bromide is dropped to the above contents with stirring under a nitrogen gas flow. After the completion of the dropping, the resulting reaction solution is subject to reaction for 3 hours at 63.0° C. with stirring. Consequently, pentafluorophenyl magnesium bromide is obtained in the form of a diethyl ether solution. A reaction yield of pentafluorophenyl magnesium bromide found in the same manner as Example 13 is 80.3 percent by mole.

1. customAir inside a reaction vessel of the same kind as the one used in Example 13
2. customAfter the completion of the dropping, the resulting reaction solution
3. customis subject to reaction for 3 hours at 63.0° C.
4. stirringwith stirring

ORD record

ord-7bd51225ebbe46ff9719435ab8cb691a

Source dataset

uspto-grants-2004_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06683218B1