2-Bromopropane → HCID 178505971, compound

Air inside a reaction vessel of the same kind as the one used in Example 13 is displaced by a nitrogen gas in a satisfactory manner. Then, 2.650 g (0.109 mole) of magnesium, 17.469 g (0.104 mole) of pentafluorobenzene, and 10 ml of diethyl ether and 10 ml of toluene both serving as the solvent (e) (mixed solvent) are charged to the reaction vessel. Also, 14.185 g (0.109 mole) of isopropyl bromide is charged to the dropping funnel. Next, isopropyl bromide is dropped to the contents with stirring under a nitrogen gas atmosphere. After the completion of the dropping, the resulting reaction solution is subject to reaction for 2.5 hours at 69.0° C. with stirring. Consequently, pentafluorophenyl magnesium bromide is obtained in the form of a mixed solution of diethyl ether and toluene. A reaction yield of pentafluorophenyl magnesium bromide found in the same manner as Example 13 is 82.4 percent by mole.

1. customAir inside a reaction vessel of the same kind as the one used in Example 13
2. customAfter the completion of the dropping, the resulting reaction solution
3. customis subject to reaction for 2.5 hours at 69.0° C.
4. stirringwith stirring

ORD record

ord-9412da5345464ce6877f9a81ffcb9651

Source dataset

uspto-grants-2004_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06683218B1