2-Bromopropane → HCID 178505971, compound

HRID 1841685Notes

Reaction equation

HRID 1841685 reaction equation
[Mg:1].[F:2][C:3]1[C:4]([F:12])=[C:5]([F:11])[C:6]([F:10])=[C:7]([F:9])[CH:8]=1.C([Br:16])(C)C>C(OCC)C>[F:2][C:3]1[C:8]([Mg:1][Br:16])=[C:7]([F:9])[C:6]([F:10])=[C:5]([F:11])[C:4]=1[F:12]

Participants

5

Reactant 3

HCID 63582-Bromopropane2×HCID 9696PentafluorobenzeneHCID 5462224Magnesium

Product 1

HCID 178505971HCID 178505971, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

Air inside a reaction vessel of the same kind as the one used in Example 13 is displaced by a nitrogen gas in a satisfactory manner. Then, 1.503 g (0.062 mole) of magnesium, 9.770 g (0.058 mole) of pentafluorobenzene, and 15 ml of diethyl ether are charged to the reaction vessel. Also, 8.169 g (0.063 mole) of isopropyl bromide is charged to the dropping funnel. Next, isopropyl bromide is dropped to the above content with stirring under a nitrogen gas flow. After the completion of the dropping, the resulting reaction solution is subject to reaction for 2 hours at 58.0° C. with stirring. Consequently, pentafluorophenyl magnesium bromide is obtained in the form of a diethyl ether solution. A reaction yield of pentafluorophenyl magnesium bromide found in the same manner as Example 13 is 84.0 percent by mole.

Workup

  1. customAir inside a reaction vessel of the same kind as the one used in Example 13
  2. customAfter the completion of the dropping, the resulting reaction solution
  3. customis subject to reaction for 2 hours at 58.0° C.
  4. stirringwith stirring

Sources & evidence

ORD record
ord-6e440bfa04684742a9a963bbd1c80986
Source dataset
uspto-grants-2004_01
Patent number
US06683218B1

Reaction notes

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