Hydrochloric Acid → HCID 85875172, compound

HRID 1841880Notes

Reaction equation

HRID 1841880 reaction equation
C(=O)([O-])O.[K+].Cl[CH2:7][C:8]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[O:9].[C-:19]#[N:20].[K+].Cl>O>[C:19]([CH2:7][C:8]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[O:9])#[N:20]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 9032Potassium CyanideHCID 516893Potassium BicarbonateHCID 21040516-(2-chloroacetamido)hexanoic acid

Product 1

HCID 85875172HCID 85875172, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2.8 g (20 mMol) potassium hydrogen carbonate was added to 8.3 g (40 mMol) 6-(chloracetamido) hexanoic acid dissolved in 25 ml water. 3.2 g (48 mMol) potassium cyanide was then added to the clear solution which was cooled on ice. The reaction mixture was stirred for 17 hours and was then acidified with HCl (2 N). The residue after extraction was purified by chromatography (silica gel, solvent: ethyl acetate).

Workup

  1. temperaturewas cooled on ice
  2. extractionThe residue after extraction
  3. customwas purified by chromatography (silica gel, solvent: ethyl acetate)

Sources & evidence

ORD record
ord-6f2b258e274f4d5e903946bd21fbb62f
Source dataset
uspto-grants-2015_02
Patent number
US08946129B2

Reaction notes

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