Trifluoroacetic acid → HCID 52938413, compound

HRID 1841940Notes

Reaction equation

HRID 1841940 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[CH:22]=[CH:21][C:20]([NH:23][C:24](=[O:27])[CH:25]=[CH2:26])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:7][CH:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[CH:22]=[CH:21][C:20]([NH:23][C:24](=[O:27])[CH:25]=[CH2:26])=[CH:19][CH:18]=2)(=[O:15])=[O:16])[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 52938411HCID 52938411, compound

Product 1

HCID 52938413HCID 52938413, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of [1-(4-Acryloylamino-benzenesulfonyl)-piperidin-4-yl]-carbamic acid tert-butyl ester (0.57 g, 1.4 mmol) in DCM (10 ml) was added trifluoroacetic acid (10 ml) in one portion. The resulting mixture was then stirred at room temperature under a nitrogen atmosphere for 3 hours. After this time the reaction was concentrated under vacuum to afford the title compound (0.40 g, 93% yield) as an orange solid.

Workup

  1. concentrationAfter this time the reaction was concentrated under vacuum

Sources & evidence

ORD record
ord-84f162f0efa241cc862610efe0346cc2
Source dataset
uspto-grants-2015_02
Patent number
US08946197B2

Reaction notes

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