Trifluoroacetic acid → HCID 67193956, compound

HRID 1841947Notes

Reaction equation

HRID 1841947 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[CH:22]=[CH:21][C:20]([NH:23][C:24](=[O:27])[CH:25]=[CH2:26])=[CH:19][C:18]=2[O:28][CH3:29])(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:29][O:28][C:18]1[CH:19]=[C:20]([NH:23][C:24](=[O:27])[CH:25]=[CH2:26])[CH:21]=[CH:22][C:17]=1[S:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)(=[O:16])=[O:15]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 56954827HCID 56954827, compound

Product 1

HCID 67193956HCID 67193956, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-(4-Acryloylamino-2-methoxy-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (2.0 g, 4.7 mmol) in DCM (20 ml) was added trifluoroacetic acid (5 ml) in one portion. The resulting mixture was then stirred at room temperature under a nitrogen atmosphere for 3 hours. After this time the reaction was concentrated under vacuum to afford the title compound (1.3 g, 93% yield) as an orange gum.

Workup

  1. concentrationAfter this time the reaction was concentrated under vacuum

Sources & evidence

ORD record
ord-92042a917b344a2f939a4fe208bdcfb6
Source dataset
uspto-grants-2015_02
Patent number
US08946197B2

Reaction notes

Loading…