反应详情

A 5 N sodium hydroxide solution (3 mL) and ethanol (3 mL) were added to a solution of methyl 5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxylate obtained in Preparation Example 50-(1) (197 mg) in THF (5 mL), and the mixture was heated under reflux for 15 minutes. After returning to room temperature, water and ethyl acetate were added and the aqueous layer was separated. The aqueous layer was adjusted to pH 1 with hydrochloric acid, and ethyl acetate was added to the aqueous layer. The organic layer was separated and dried over anhydrous magnesium sulfate. The organic layer was concentrated under reduced pressure to obtain the title compound (87 mg).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 15 minutes
3. customAfter returning to room temperature
4. customthe aqueous layer was separated
5. additionwas added to the aqueous layer
6. customThe organic layer was separated
7. dry with materialdried over anhydrous magnesium sulfate
8. concentrationThe organic layer was concentrated under reduced pressure