Hydrochloric Acid → HCID 57827789, compound

HRID 1842126Notes

Reaction equation

HRID 1842126 reaction equation
[OH-].[Na+].[F:3][CH2:4][CH2:5][O:6][C:7]1[N:8]=[CH:9][C:10]([C:13]([O:15]C)=[O:14])=[N:11][CH:12]=1.Cl.[Cl-].[Na+]>C(O)C.C(OCC)(=O)C.O>[F:3][CH2:4][CH2:5][O:6][C:7]1[N:8]=[CH:9][C:10]([C:13]([OH:15])=[O:14])=[N:11][CH:12]=1

Participants

8

Reactant 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 14798Sodium HydroxideHCID 57827374HCID 57827374, compound

Product 1

HCID 57827789HCID 57827789, compound

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Procedure

A 5 N sodium hydroxide solution (400 μL) was added to a solution of methyl 5-(2-fluoroethoxy)pyrazine-2-carboxylate obtained in Preparation Example 53-(1) (200 mg) in ethanol (4 mL). Water was added until the reaction solution became a complete solution, followed by stirring at room temperature for 10 minutes. The reaction solution was made acidic with 5 N hydrochloric acid. Saturated aqueous sodium chloride and ethyl acetate were added to the reaction solution, and the organic layer was separated. The organic layer was dried over anhydrous magnesium sulfate. The organic layer was concentrated under reduced pressure to obtain the title compound (150 mg).

Workup

  1. customthe organic layer was separated
  2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  3. concentrationThe organic layer was concentrated under reduced pressure

Sources & evidence

ORD record
ord-9722d0f06376476eb8176c068a8d7366
Source dataset
uspto-grants-2015_02
Patent number
US08946211B2

Reaction notes

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