反应详情

温度

80 °C

Cesium carbonate (2.12 g) and 2-bromo-1,1-difluoroethane (939 mg) were added to a solution of methyl 5-hydroxypyrazine-2-carboxylate (500 mg) in DMF (20 mL), and the mixture was stirred at 80° C. for four hours. The reaction solution was returned to room temperature. Saturated aqueous sodium chloride and ethyl acetate were added and the organic layer was separated. The organic layer was dried over anhydrous magnesium sulfate. The organic layer was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to obtain the title compound (145 mg).

1. customwas returned to room temperature
2. customthe organic layer was separated
3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
4. concentrationThe organic layer was concentrated under reduced pressure
5. customThe residue was purified by silica gel column chromatography