反应详情

To a solution of crude 1-bromo-5-fluoro-2-methyl-3-nitro-benzene (5.96 g) in MeOH (90 mL) was added concentrated hydrochloric acid (11.7 mL) and iron (6.1 g) and the reaction mixture was heated to reflux. After 16 h, the mixture was cooled, diluted with DCM, washed with sodium carbonate solution, dried (MgSO4) and the solvent removed in vacuo. The residue was purified using flash chromatography to yield 3-bromo-5-fluoro-2-methyl-phenylamine (1.46 g).

1. temperaturethe reaction mixture was heated to reflux
2. temperaturethe mixture was cooled
3. washwashed with sodium carbonate solution
4. dry with materialdried (MgSO4)
5. customthe solvent removed in vacuo
6. customThe residue was purified