Hydrochloric Acid → HCID 58465662, compound

HRID 1842466Notes

Reaction equation

HRID 1842466 reaction equation
[CH3:1][C:2]1[C:3]2[CH:26]=[CH:25][CH:24]=[CH:23][C:4]=2[S:5][C:6]=1[C:7]([N:9]1[CH2:14][CH2:13][N:12]2[N:15]=[C:16]([C:18]([O:20]CC)=[O:19])[CH:17]=[C:11]2[CH2:10]1)=[O:8].[OH-].[Na+].Cl>O1CCCC1.CO>[CH3:1][C:2]1[C:3]2[CH:26]=[CH:25][CH:24]=[CH:23][C:4]=2[S:5][C:6]=1[C:7]([N:9]1[CH2:14][CH2:13][N:12]2[N:15]=[C:16]([C:18]([OH:20])=[O:19])[CH:17]=[C:11]2[CH2:10]1)=[O:8]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 58465666HCID 58465666, compound

Product 1

HCID 58465662HCID 58465662, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

The ethyl 5-(3-methylbenzo[b]thiophene-2-carbonyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate obtained in the previous step was dissolved in a mixture of tetrahydrofuran (1.8 mL) and methanol (0.3 mL). To the resulting solution was added 1M aqueous sodium hydroxide (0.4 mL, 0.4 mmol). The solution was stirred at room temperature for 4 hours whereupon the reaction was neutralized with the addition of 1M aqueous hydrochloric acid (0.4 mL). The solvents were evaporated under reduced pressure to afford crude Intermediate 24 as a white solid.

Workup

  1. customThe solvents were evaporated under reduced pressure

Sources & evidence

ORD record
ord-cc9fe4bb770b490b94e7d7e5cddaacf6
Source dataset
uspto-grants-2015_02
Patent number
US08946223B2

Reaction notes

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