Hydrochloric Acid → HCID 178509513, compound

HRID 1842481Notes

Reaction equation

HRID 1842481 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([C:13]2[NH:17][C:16]3[CH:18]=[CH:19][C:20]([C:22]#[N:23])=[CH:21][C:15]=3[N:14]=2)[CH2:9]1)=O)(C)(C)C.Cl>CO>[NH:8]1[CH2:12][CH2:11][CH:10]([C:13]2[NH:17][C:16]3[CH:18]=[CH:19][C:20]([C:22]#[N:23])=[CH:21][C:15]=3[N:14]=2)[CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178451786HCID 178451786, compound

Product 1

HCID 178509513HCID 178509513, compoundYield 130.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The 3-(5-cyano-1H-benzoimidazol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester (9 g, 28.8 mmol) in a solution of 4M HCl in MeOH (50 mL) was stirred at 60° C. for 1 h, then it was concentrated to give the crude product (8 g, 79%). The crude product was used in the next step without further purification.

Workup

  1. concentrationit was concentrated

Sources & evidence

ORD record
ord-6f54737347364ad0a3d9062c60c42ce7
Source dataset
uspto-grants-2015_02
Patent number
US08946230B2

Reaction notes

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