反应详情

Compound 4 (0.005 mol, 0.835 g) was added to a solution of 4-methoxy-N-methylaniline (5, 0.006 mol, 0.822 g) in i-propanol (10 ml) with drops of conc. HCl. The resulting solution was transferred to a microwave vial (20 ml) and irradiated at 110° C. After 6 h, the reaction was completed and AAG20 was obtained after the chromatographic purification as a white solid (1.01 g) with 80% yield. TLC Rf=0.85 (CH3OH:CHCl3=1:5). 1H NMR (DMSO-d6): δ 2.65 (s, 3H, 2-CH3), 3.62 (s, 3H, N—CH3), 3.84 (s, 3H, OCH3), 6.99 (bs, 4H, C6H4), 7.11-7.13 (d, 1H, 5-H), 7.39-7.41 (d, 1H, 6-H), 12.44 (s, 1H, 7-H, D2O exchanged). Anal. Calcd. (C15H16N4O. 0.3688 CHCl3.), C, 59.10; H, 5.28; N, 17.94; Found C, 58.98; H, 5.65; N, 18.16.

1. customirradiated at 110° C
2. customAAG20 was obtained
3. customafter the chromatographic purification as a white solid (1.01 g) with 80% yield