HCID 70816329, compound → HCID 64768098, compound

HRID 1842943Notes

Reaction equation

HRID 1842943 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[CH2:11][O:12][CH2:13][CH2:14][O:15][CH3:16]>C1COCC1.[Pd]>[F:1][C:2]1[CH:7]=[C:6]([CH:5]=[CH:4][C:3]=1[CH2:11][O:12][CH2:13][CH2:14][O:15][CH3:16])[NH2:8]

Participants

4

Reactant 1

HCID 70816329HCID 70816329, compound

Product 1

HCID 64768098HCID 64768098, compoundYield 72%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

To a stirred solution of 2-fluoro-1-((2-methoxyethoxy)methyl)-4-nitrobenzene (4.0 g, 1.0 eq) in THF (50 mL) was added 10% Pd—C and the reaction mixture was stirred under H2 gas balloon at for 16 h. The reaction mixture was passed through celite pad and the solvent evaporated to get 3-fluoro-4-((2-methoxyethoxy)methyl)aniline (2.50 g, 72%) as solid (TLC system: EtOAc/PE (1:1), Rf: 0.3).

Workup

  1. customthe solvent evaporated

Sources & evidence

ORD record
ord-40cd28c942804194abc9f18a9aa4a381
Source dataset
uspto-grants-2015_02
Patent number
US08946204B2

Reaction notes

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