Trifluoroacetic acid → 2-(4-(Ethylsulfonamidomethyl)-3-fluorophenyl)propanoic acid

HRID 1842987Notes

Reaction equation

[CH2:1]([S:3]([NH:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]([CH3:20])[C:15]([O:17]CC)=[O:16])=[CH:10][C:9]=1[F:21])(=[O:5])=[O:4])[CH3:2].C(O)(C(F)(F)F)=O>CN(C=O)C.[Mn]>[CH2:1]([S:3]([NH:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]([CH3:20])[C:15]([OH:17])=[O:16])=[CH:10][C:9]=1[F:21])(=[O:5])=[O:4])[CH3:2]

Participants

Conditions

Temperature: 65 °C

Procedure

To a solution of ethyl 2-(4-(ethylsulfonamidomethyl)-3-fluorophenyl)propanoate (305 mg, 1.03 mmol) in DMF, manganese (113 mg, 2.06 mmol), NiBr2bipy (27 mg, 0.07 mmol), ethyl-2-chloro propionate (0.17 mL, 1.34 mmol) was added, followed by addition of TFA (0.002 mL, 0.028 mmol). The mixture was stirred for 1 day at 65° C. The reaction mixture was quenched by conc. HCl (7-drops) and then extracted with diethyl ether, dried (MgSO4) and the solvent was evaporated in vacuo. The residue was purified by CC (EtOAc/n-hexane). 2-(4-(ethyl-sulfonamidomethyl)-3-fluorophenyl)propanoic acid in pure form (65 mg, 20%) was obtained.

Workup

customThe reaction mixture was quenched by conc. HCl (7-drops)
extractionextracted with diethyl ether
dry with materialdried (MgSO4)
customthe solvent was evaporated in vacuo
customThe residue was purified by CC (EtOAc/n-hexane)

Sources & evidence

ORD record: ord-5a0a674743504fb2a83b21ff1159eeaf
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08946204B2

Reaction notes

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