反应详情

温度

70 °C

2.1 g (11 mmol) of 3-(3-nitrophenyl)-1H-pyrazole were dissolved in 25 ml of dry dimethylformamide and 2.63 g (11.7 mmol) of N-iodosuccinimide were added. After 5 hours under stirring at 70° C. the most part of solvent was removed in vacuo and an aqueous solution of sodium thiosulphate was added and the product extracted several times with dichloromethane. The organic phase was then dried over sodium sulphate and evaporated to give, after trituration with diisopropylether, 2.6 g (74%) of the title compound.

1. customwas removed in vacuo
2. additionan aqueous solution of sodium thiosulphate was added
3. extractionthe product extracted several times with dichloromethane
4. dry with materialThe organic phase was then dried over sodium sulphate
5. customevaporated
6. customto give