反应详情

A solution of t-butyl bromoacetate (506 g, 2.59 mol), methyl 3-hydroxybenzoate (395 g, 2.60 mol) and potassium carbonate (789 g, 5.71 mol) in DMF (2 L) was stirred at room temperature for two hours. The reaction mixture was concentrated and then water (1 L) was added, followed by extraction with ethyl acetate (2 L). The organic layer was washed with water (1 L) twice, dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain t-butyl [3-(methoxycarbonyl)phenoxy]acetate as a colorless oil.

1. concentrationThe reaction mixture was concentrated
2. additionwater (1 L) was added
3. extractionfollowed by extraction with ethyl acetate (2 L)
4. washThe organic layer was washed with water (1 L) twice
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated under reduced pressure