Pyridine, hydrofluoride (1:1) → HCID 66705837, compound

HRID 1843709Notes

Reaction equation

HRID 1843709 reaction equation
[Br:1][C:2]1[C:3](N)=[N:4][CH:5]=[C:6]([Br:9])[C:7]=1[Cl:8].N([O-])=O.[Na+].N1C=CC=CC=1.[FH:21]>>[Br:1][C:2]1[C:3]([F:21])=[N:4][CH:5]=[C:6]([Br:9])[C:7]=1[Cl:8]

Participants

4

Reactant 3

HCID 64774Pyridine, hydrofluoride (1:1)HCID 23668193Sodium NitriteHCID 667059143,5-DibroMo-4-chloro-pyridin-2-ylaMine

Product 1

HCID 66705837HCID 66705837, compoundYield 83%

Procedure

The reaction and post-treatment were carried out according to Example (8a) using 3,5-dibromo-4-chloropyridin-2-amine produced in Example (14a) (10.1 g, 35.4 mmol), sodium nitrite (3.66 g, 53.1 mmol) and hydrogen fluoride-pyridine (50 mL) to obtain the title compound (8.50 g, 83%) as a pale yellow oil.

Workup

  1. customThe reaction

Sources & evidence

ORD record
ord-44971ca8e29b4ac190f89b48945cd083
Source dataset
uspto-grants-2015_02
Patent number
US08946264B2

Reaction notes

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