Nitromethane → HCID 66692011, compound

HRID 1843937Notes

Reaction equation

[F:1][C:2]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:3]=1[CH:4]=O.[N+:12]([CH3:15])([O-:14])=[O:13].[OH-].[Na+]>>[F:1][C:2]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:3]=1[CH:4]=[CH:15][N+:12]([O-:14])=[O:13]

Participants

Reactant 3

HCID 6375Nitromethane

HCID 14798Sodium Hydroxide

HCID 27348722-Fluoro-5-methoxybenzaldehyde

Product 1

HCID 66692011HCID 66692011, compoundYield 58.7%

Procedure

2-Fluoro-5-methoxy-benzaldehyde (4 g, 25.95 mmol) was reacted with nitro methane (1.58 g, 25.95 mmol), 10N NaOH (2.2 mL, 27.24 mmol) to afford 3 g of the product (58.7% yield).

Sources & evidence

ORD record: ord-95563d6c339a463f9e109f1393174b1a
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08946260B2

Reaction notes

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