Nitromethane → HCID 66802111, compound

HRID 1844064Notes

Reaction equation

HRID 1844064 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][C:3]=1[O:10][CH3:11].[N+:12]([CH3:15])([O-:14])=[O:13].[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[CH:15][N+:12]([O-:14])=[O:13])=[CH:4][C:3]=1[O:10][CH3:11]

Participants

5

Reactant 3

HCID 6375NitromethaneHCID 14798Sodium HydroxideHCID 129097254-Chloro-3-methoxybenzaldehyde

Product 1

HCID 66802111HCID 66802111, compoundYield 66.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
0 °C

Procedure

4-Chloro-3-methoxybenzaldehyde (1 g, 5.88 mmol) in ethanol (10 mL) was reacted with nitro methane (358 mg, 5.88 mmol) and 10N NaOH (0.6 mL, 28.11 mmol). The resulting mixture was stirred at 0° C. for 3 hours to afford 800 mg of the product (66.6% yield).

Sources & evidence

ORD record
ord-6f2a8dcdd4264326b87fc2a6f50ba820
Source dataset
uspto-grants-2015_02
Patent number
US08946260B2

Reaction notes

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