Hydrochloric Acid → HCID 70872880, compound

HRID 1844248Notes

Reaction equation

HRID 1844248 reaction equation
[ClH:1].[NH2:2][C:3](=[O:32])[CH2:4][N:5]([C@@H:13]1[CH2:15][C@H:14]1[C:16]1[CH:21]=[CH:20][C:19]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][C:27]([C:30]#[N:31])=[CH:26][CH:25]=2)=[CH:18][CH:17]=1)C(=O)OC(C)(C)C>>[ClH:1].[C:30]([C:27]1[CH:26]=[CH:25][C:24]([CH2:23][O:22][C:19]2[CH:20]=[CH:21][C:16]([C@@H:14]3[CH2:15][C@H:13]3[NH:5][CH2:4][C:3]([NH2:2])=[O:32])=[CH:17][CH:18]=2)=[CH:29][CH:28]=1)#[N:31]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67115807HCID 67115807, compound

Product 1

HCID 70872880HCID 70872880, compoundYield 100%

Procedure

HCl (2 M ethereal solution, 1 mL, 2 mmol) was added to a flask containing tert-butyl 2-amino-2-oxoethyl[(trans)-2-{4-[(4-cyanobenzyl)oxy]phenyl}cyclopropyl]carbamate (36 mg, 0.09 mmol) and the mixture was stirred at room temperature for 24 h. After removal of the solvent, the solid was washed with Et2O (2×2 mL) and vacuum dried, rendering 29 mg of 2-[((trans)-2-{4-[(4-cyanobenzyl)oxy]phenyl}cyclopropyl)amino]acetamide hydrochloride salt (white solid, 100% yield).

Workup

  1. customAfter removal of the solvent
  2. washthe solid was washed with Et2O (2×2 mL) and vacuum
  3. customdried

Sources & evidence

ORD record
ord-08b07febf0bc47b0ae4d79c0b610cb39
Source dataset
uspto-grants-2015_02
Patent number
US08946296B2

Reaction notes

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