Hydrazine hydrate (1:1) → 1h-pyrrole-2-carbohydrazide

HRID 1844303Notes

Reaction equation

HRID 1844303 reaction equation
O.[NH2:2][NH2:3].[NH:4]1[CH:8]=[CH:7][CH:6]=[C:5]1[C:9]([O:11]C)=O>CO>[NH:4]1[CH:8]=[CH:7][CH:6]=[C:5]1[C:9]([NH:2][NH2:3])=[O:11]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 136930Methyl pyrrole-2-carboxylate

Product 1

HCID 2816101h-pyrrole-2-carbohydrazide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
65 °C

Procedure

Hydrazine monohydrate (31.0 g, 620 mmol) was added to a mixture of methyl 1H-pyrrole-2-carboxylate (10 g, 77.5 mmol) and methanol (100 ml) followed by stirring at 65° C. for 15 h. The mixture was evaporated and the product was isolated as a crystalline solid.

Workup

  1. customThe mixture was evaporated
  2. customthe product was isolated as a crystalline solid

Sources & evidence

ORD record
ord-7b639207863146019f25471e295025de
Source dataset
uspto-grants-2015_02
Patent number
US08946412B2

Reaction notes

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