Hydrochloric Acid → HCID 56952846, compound

HRID 1844516Notes

Reaction equation

HRID 1844516 reaction equation
[F:1][C:2]1[CH:30]=[C:29]([NH:31][CH3:32])[CH:28]=[CH:27][C:3]=1[O:4][C:5]1[N:10]=[CH:9][C:8]([NH:11][C:12](=[O:26])[C:13]2[CH:18]=[CH:17][C:16]([O:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:15][CH:14]=2)=[CH:7][CH:6]=1.[ClH:33]>CCO>[ClH:33].[F:1][C:2]1[CH:30]=[C:29]([NH:31][CH3:32])[CH:28]=[CH:27][C:3]=1[O:4][C:5]1[N:10]=[CH:9][C:8]([NH:11][C:12](=[O:26])[C:13]2[CH:14]=[CH:15][C:16]([O:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:17][CH:18]=2)=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 56952352HCID 56952352, compound

Product 1

HCID 56952846HCID 56952846, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To an EtOH (7 mL) solution of N-{6-[2-fluoro-4-(methylamino)phenoxy]pyridin-3-yl}-4-phenoxybenzamide (0.34 g) was added 6 M HCl (0.14 mL) at 0° C. The resultant mixture was stirred at 0° C. The resulting precipitate was recrystallized from EtOH/H2O to give the title compound as a white powder (0.28 g).

Workup

  1. customThe resulting precipitate was recrystallized from EtOH/H2O

Sources & evidence

ORD record
ord-706d98226c6e45aa9525ebc462122593
Source dataset
uspto-grants-2015_02
Patent number
US08946437B2

Reaction notes

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