Hydrochloric Acid → HCID 56952745, compound

HRID 1844517Notes

Reaction equation

HRID 1844517 reaction equation
[CH3:1][C:2]1[CH:27]=[C:26]([NH:28][CH3:29])[CH:25]=[CH:24][C:3]=1[O:4][C:5]1[N:10]=[CH:9][C:8]([NH:11][C:12](=[O:23])[C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=2)=[CH:7][CH:6]=1.[ClH:30]>CCO>[ClH:30].[CH3:1][C:2]1[CH:27]=[C:26]([NH:28][CH3:29])[CH:25]=[CH:24][C:3]=1[O:4][C:5]1[N:10]=[CH:9][C:8]([NH:11][C:12](=[O:23])[C:13]2[CH:14]=[CH:15][C:16]([C:19]([F:22])([F:20])[F:21])=[CH:17][CH:18]=2)=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 56952644HCID 56952644, compound

Product 1

HCID 56952745HCID 56952745, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To an EtOH (3 mL) solution of N-{6-[2-Methyl-4-(methylamino)phenoxy]pyridin-3-yl}-4-(trifluoromethyl)benzamide (0.30 g) was added 6 M aqueous HCl (0.13 mL) at 0° C. The resultant mixture was stirred at 0° C. The resulting precipitate was recrystallized from EtOH/H2O, giving the title compound as a white powder (0.20 g).

Workup

  1. customThe resulting precipitate was recrystallized from EtOH/H2O

Sources & evidence

ORD record
ord-2b4e9382fb0d4b408599d9a4f955f535
Source dataset
uspto-grants-2015_02
Patent number
US08946437B2

Reaction notes

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