Methyl iodide → HCID 86664522, compound

HRID 1844601Notes

Reaction equation

HRID 1844601 reaction equation
CI.[Cl:3][C:4]1[CH:9]=[C:8]([O:10][C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][C:19]=2[CH3:20])[C:14]([OH:16])=[O:15])[CH:7]=[CH:6][N:5]=1.[C:21](=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Cl:3][C:4]1[CH:9]=[C:8]([O:10][C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][C:19]=2[CH3:20])[C:14]([O:16][CH3:21])=[O:15])[CH:7]=[CH:6][N:5]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 86664523HCID 86664523, compound

Product 1

HCID 86664522HCID 86664522, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

At ambient temperature 1.6 ml methyl iodide are added to a mixture of 6.21 g 3-(2-chloro-pyridin-4-yloxy)-4-methyl-benzoic acid, 4.88 g potassium carbonate to and 30 ml N,N-dimethylformamide. The mixture is stirred overnight at ambient temperature. Then the mixture is added to ice-cold water, and the precipitate is filtered off and dried at 45° C.

Workup

  1. additionThen the mixture is added to ice-cold water
  2. filtrationthe precipitate is filtered off
  3. customdried at 45° C.

Sources & evidence

ORD record
ord-54553598e88c4d47adeb5cde2f19fdc3
Source dataset
uspto-grants-2015_02
Patent number
US08946438B2

Reaction notes

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