Dimethylformamide → 4-(1-Phenyl-1-(thiazol-2-yl)-methylene)-piperidine-1-carboxylic Acid tert-butyl Ester

HRID 184463Notes

Reaction equation

HRID 184463 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11](=[C:14]([c:15]2[cH:16][cH:17][cH:18][cH:19][cH:20]2)[Br:21])[CH2:12][CH2:13]1.[CH2:22]([Sn:23]([CH2:24][CH2:25][CH2:26][CH3:32])([c:27]1[s:28][cH:29][cH:30][n:31]1)[CH2:33][CH2:34][CH2:35][CH3:36])[CH2:37][CH2:38][CH3:39].[Cu:45][I:46].[O:40]=[CH:41][N:42]([CH3:43])[CH3:44]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11](=[C:14]([c:15]2[cH:16][cH:17][cH:18][cH:19][cH:20]2)[c:27]2[s:28][cH:29][cH:30][n:31]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 27632592-(Tributylstannyl)-1,3-thiazoleHCID 590345854-(1-Bromo-1-phenyl-methylene)-piperidine-1-carboxylic Acid tert-butyl Ester

Product 1

HCID 670467134-(1-Phenyl-1-(thiazol-2-yl)-methylene)-piperidine-1-carboxylic Acid tert-butyl Ester

Sources & evidence

ORD record
ord-e14b5775b9e64c93adea6f59f55a1d8b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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