Hydroxyamine hydrochloride → HCID 136408146, compound

HRID 1844684Notes

Reaction equation

HRID 1844684 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:5]([OH:11])=[C:6]([C:8](=O)[CH3:9])[CH:7]=1.CC([O-])=O.[Na+].[NH2:21][OH:22].Cl>CCO>[Br:1][C:2]1[CH:3]=[C:4]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:5]([OH:11])=[C:6]([C:8](=[N:21][OH:22])[CH3:9])[CH:7]=1

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 84712940HCID 84712940, compound

Product 1

HCID 136408146HCID 136408146, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1-(5-bromo-3-(tert-butyl)-2-hydroxyphenyl)ethanone (0.5 g, 1.8 mmol), NaOAc (246 mg, 3.0 mmol) and NH2OH.HCl (187 mg, 2.7 mmol) in EtOH (10 mL) was heated at reflux for 3 h, concentrated and the obtained solid was washed with water to give compound P8a (0.5 g, 97%) as solid.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 3 h
  3. concentrationconcentrated
  4. washthe obtained solid was washed with water
  5. customto give compound P8a (0.5 g, 97%) as solid

Sources & evidence

ORD record
ord-9cfe3a9d89924c158d21700b49d2719e
Source dataset
uspto-grants-2015_02
Patent number
US08946446B2

Reaction notes

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