Oxalyl chloride → HCID 86719134, compound

HRID 1844721Notes

Reaction equation

HRID 1844721 reaction equation
[CH:1]1([CH2:7][N:8]2[C:12]([C:13]3[CH:18]=[C:17]([C:19]([CH3:22])([CH3:21])[CH3:20])[CH:16]=[C:15]([C:23]([CH3:26])([CH3:25])[CH3:24])[CH:14]=3)=[CH:11][C:10]([S:27](O)(=[O:29])=[O:28])=[C:9]2[CH3:31])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(Cl)(C([Cl:36])=O)=O>C(Cl)Cl>[CH:1]1([CH2:7][N:8]2[C:12]([C:13]3[CH:18]=[C:17]([C:19]([CH3:22])([CH3:21])[CH3:20])[CH:16]=[C:15]([C:23]([CH3:26])([CH3:25])[CH3:24])[CH:14]=3)=[CH:11][C:10]([S:27]([Cl:36])(=[O:29])=[O:28])=[C:9]2[CH3:31])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 86719135HCID 86719135, compound

Product 1

HCID 86719134HCID 86719134, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of compound 5c (1.0 g, 2.2 mmol) in CH2Cl2 (10 mL) was added (COCl)2 (0.8 g, 6.6 mmol) dropwise at 0° C. Then this mixture was stirred at 0° C. for 2 h and concentrated to obtain compound 5d (1.0 g, 100%).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-166c86e6d4c24b0192d6909682956c05
Source dataset
uspto-grants-2015_02
Patent number
US08946446B2

Reaction notes

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