Ammonium Hydroxide → HCID 54704836, compound

HRID 1844730Notes

Reaction equation

HRID 1844730 reaction equation
[C:1]([C:5]1[O:10][C:9](=O)[CH:8]=[C:7]([OH:12])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH4+:13].[OH-]>C1(C)C=CC=CC=1>[C:1]([C:5]1[NH:13][C:9](=[O:10])[CH:8]=[C:7]([OH:12])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 54687263HCID 54687263, compound

Product 1

HCID 54704836HCID 54704836, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 6-(tert-butyl)-4-hydroxy-2H-pyran-2-one (38 g, 168 mmol) and aq. NH4OH (150 mL, 30%) in dry toluene (200 mL) was heated at reflux for 1 h. The resulting mixture was concentrated and purified by CC (PE/EA=5/1) to give compound 17a (22.5 g, 80%) as a white solid.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 1 h
  3. concentrationThe resulting mixture was concentrated
  4. custompurified by CC (PE/EA=5/1)

Sources & evidence

ORD record
ord-3aa3da48cbfa4b77902b3f7462ee44d8
Source dataset
uspto-grants-2015_02
Patent number
US08946446B2

Reaction notes

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