反应详情

To a solution of compound 27d (29.4 g, 146 mmol), bromocyclohexylmethane (30.9 g, 175 mmol), K2CO3 (40.2 g, 291 mmol) in dry DMF (300 mL) was heated at 85° C. overnight, quenched with water and extracted with EA twice. The combined organic layers were washed with water (3×) and brine, concentrated and purified by CC (PE/EA=2/1) to give compound 27e (17.8 g, 41%) as a solid.

1. customquenched with water
2. extractionextracted with EA twice
3. washThe combined organic layers were washed with water (3×) and brine
4. concentrationconcentrated
5. custompurified by CC (PE/EA=2/1)