反应详情

温度

80 °C

In a dried reaction flask, 4-fluoro-2-methylbenzonitrile (4.055 g, 30.0 mmol) and hydrazine hydrate (85%) (3.54 mL, 60.0 mmol) were dissolved in ethanol (15.9 mL). In the protection from light and under the nitrogen atmosphere, the solution was heated under reflux at 80° C. for 48 hr. Water was added to the reaction solution. The mixture was filtered. The filtered cake was rinsed with water to produce a pale yellow solid, which was suspended in ethyl ether. A hydrogen chloride gas was passed into the suspension under an ice-salt bath. The suspension was filtered. The filtered cake was rinsed with ethyl ether to produce an off-white solid (2.04 g) in 37.0% yield.

1. temperatureIn the protection from light and under the nitrogen atmosphere, the solution was heated
2. filtrationThe mixture was filtered
3. washThe filtered cake was rinsed with water
4. customto produce a pale yellow solid, which
5. filtrationThe suspension was filtered
6. washThe filtered cake was rinsed with ethyl ether