反应详情

In a dried reaction flask, butyl 4-aminopiperidine-1-carboxylate (2.0 g, 10.0 mmol), methanesulfonyl chloride (0.77 mL, 10 mmol), and DIEA (2.6 mL, 15 mmol) were added to dichloromethane (40 mL). The mixture was stirred under an ice-water bath for 2 hr. LC-MS showed that the product was formed and the reactants vanished. The solution was concentrated under reduced pressure to produce a yellow oil. Water was added and the mixture was extracted with ethyl acetate. The organic phase was washed with water and brine, dried over anhydrous sodium sulfate, and was purified with silica-gel column chromatography (ethyl acetate:petroleum ether=1:2) to obtain a white solid (2.67 g) in 96.0% yield.

1. customwas formed
2. concentrationThe solution was concentrated under reduced pressure
3. customto produce a yellow oil
4. extractionthe mixture was extracted with ethyl acetate
5. washThe organic phase was washed with water and brine
6. dry with materialdried over anhydrous sodium sulfate
7. customwas purified with silica-gel column chromatography (ethyl acetate:petroleum ether=1:2)