Triethylamine → HCID 66940393, compound

HRID 1845062Notes

Reaction equation

HRID 1845062 reaction equation
[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[C:8](F)[CH:7]=[C:6]([NH2:11])[C:5]=1[N+:12]([O-:14])=[O:13].C(N(CC)CC)C.[O:23]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[Na].C(O)[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[CH2:1]([O:2][C:3](=[O:15])[C:4]1[CH:9]=[C:8]([O:23][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:7]=[C:6]([NH2:11])[C:5]=1[N+:12]([O-:14])=[O:13])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 58724451Methyl 3-amino-5-fluoro-2-nitrobenzoateHCID 178519536HCID 178519536, compound

Product 1

HCID 66940393HCID 66940393, compound

Procedure

3.0 g (14.0 mmol) of 3-amino-5-fluoro-2-nitro-benzoic acid methyl ester in 1.6 g (15.4 mmol) of triethylamine and 2.1 g (15.4 mmol) of NaOBn/BnOH was heated at 60° C. for 0.5 h to produce 3-amino-5-benzyloxy-2-nitro-benzoic acid benzyl ester. LCMS: 380 (M+1)+.

Sources & evidence

ORD record
ord-6b9d53ad51614b8991d92ef0e95e1de2
Source dataset
uspto-grants-2015_02
Patent number
US08946259B2

Reaction notes

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