反应详情

温度

0 °C

A mixture of methyl 3-bromo-5-formylbenzoate (200 mg, 0.82 mmol), methanol (3 mL), 2.0 M dimethylamine solution in THF (0.3 mL, 6 mmol), zinc dichloride (30 mg, 0.22 mmol), and sodium cyanoborohydride (200 mg, 3.2 mmol) was stirred at 0° C. for 1 h. The mixture was diluted with water (10 mL) and the aqueous layer was extracted with EtOAc (15 mL×3). The combined organic layers were dried over anhydrous MgSO4 and concentrated. The residue was purified by silica gel chromatography to afford the title compound.

1. extractionthe aqueous layer was extracted with EtOAc (15 mL×3)
2. dry with materialThe combined organic layers were dried over anhydrous MgSO4
3. concentrationconcentrated
4. customThe residue was purified by silica gel chromatography