Hydrochloric Acid → 1-(2-Aminopyrimidin-4-yl)ethan-1-one

HRID 1845859Notes

Reaction equation

HRID 1845859 reaction equation
C[O:2][C:3]([C:7]1[CH:12]=[CH:11][N:10]=[C:9]([NH2:13])[N:8]=1)(OC)[CH3:4].Cl>O1CCCC1>[NH2:13][C:9]1[N:8]=[C:7]([C:3](=[O:2])[CH3:4])[CH:12]=[CH:11][N:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 135822684-(1,1-Dimethoxyethyl)pyrimidin-2-amine

Product 1

HCID 135822701-(2-Aminopyrimidin-4-yl)ethan-1-oneYield 83.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a stirred solution of 4-(1,1-dimethoxyethyl)pyrimidin-2-amine (2a) (180 g) in tetrahydrofuran (2 L) was added 2M hydrochloric acid solution (980 mL) and stirring continued at room temperature overnight. Most of the solvent was removed in vacuo and remaining aqueous solution was poured into an aqueous saturated sodium hydrogen carbonate solution. The sandy coloured precipitate was filtered off and dried in vacuo at 40° C. to give the title compound (112 g).

Workup

  1. customMost of the solvent was removed in vacuo
  2. additionwas poured into an aqueous saturated sodium hydrogen carbonate solution
  3. filtrationThe sandy coloured precipitate was filtered off
  4. customdried in vacuo at 40° C.

Sources & evidence

ORD record
ord-7be1c8cddcd04102a2e8421fe63470c4
Source dataset
uspto-grants-2015_02
Patent number
US08952001B2

Reaction notes

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