反应详情

温度

110 °C

To 2-(4′-(ethylsulfonyl)-2′-fluoro-6-methoxy-[1,1′-biphenyl]-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (Preparation 69, 90 mg, 0.21 mmol) in dioxane (2.5 mL) and water (1 mL) was added 4-chloro-7-ethyl-7H-imidazo[4,5-c]pyridazine (Preparation 8, 40 mg, 0.21 mmol) and sodium carbonate (68 mg, 0.64 mmol). The reaction was degassed and tetrakis(triphenylphosphine) palladium(0) (25 mg, 0.02 mmol) was added. The reaction was further degassed and then heated to 110° C. for 2 hours and then cooled to room temperature. The reaction mixture was diluted with EtOAc (40 mL) was passed through celite and the solvent removed in vacuo. The crude material was purified by reverse phase column chromatography eluting with a gradient of 0.1% formic acid in MeCN/water. The resulting residue was dissolved in DMSO (1 mL) and purified using preparative HPLC to give the title compound as a colourless solid in 26% yield, 24 mg.

1. customThe reaction was degassed
2. customThe reaction was further degassed
3. temperaturecooled to room temperature
4. additionThe reaction mixture was diluted with EtOAc (40 mL)
5. customthe solvent removed in vacuo
6. customThe crude material was purified by reverse phase column chromatography
7. washeluting with a gradient of 0.1% formic acid in MeCN/water
8. dissolutionThe resulting residue was dissolved in DMSO (1 mL)
9. custompurified