Dichloromethane ethanol → HCID 58483478, compound

HRID 1846091Notes

Reaction equation

HRID 1846091 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:24])[C:10]2[CH:15]=[C:14]([N+:16]([O-])=O)[CH:13]=[N:12][C:11]=2[O:19][CH2:20][CH:21]([F:23])[F:22])=[CH:4][CH:3]=1.C(Cl)Cl.CCO>C1COCC1.[Ni]>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:24])[C:10]2[CH:15]=[C:14]([NH2:16])[CH:13]=[N:12][C:11]=2[O:19][CH2:20][CH:21]([F:22])[F:23])=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 21584144Dichloromethane ethanolHCID 86658671HCID 86658671, compound

Product 1

HCID 58483478HCID 58483478, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to Example 4b from N-(4-bromophenyl)-2-(2,2-difluoroethyl)oxy-5-nitronicotinic acid amide and Ra-Ni in THF. Yield: (quantitative). MS [m+H]+=372 (Br-isotope pattern); TLC: Rf=0.60 (silica gel, DCM:EtOH 9:1).

Sources & evidence

ORD record
ord-9d5769b374b748c99c4a220af8db799f
Source dataset
uspto-grants-2015_02
Patent number
US08951999B2

Reaction notes

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