2-Chloro-5-[(2,2-dimethylpropanamido)methyl]benzoic acid → HCID 86658672, compound

HRID 1846092Notes

Reaction equation

HRID 1846092 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:22])[C:10]2[CH:15]=[C:14]([NH2:16])[CH:13]=[N:12][C:11]=2[O:17][CH2:18][CH:19]([F:21])[F:20])=[CH:4][CH:3]=1.[Cl:23][C:24]1[CH:32]=[CH:31][C:30]([CH2:33][NH:34][C:35]([C:37]([CH3:40])([CH3:39])[CH3:38])=[O:36])=[CH:29][C:25]=1[C:26](O)=[O:27]>C1COCC1>[F:21][CH:19]([F:20])[CH2:18][O:17][C:11]1[C:10]([C:9]([NH:8][C:5]2[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=2)=[O:22])=[CH:15][C:14]([NH:16][C:26](=[O:27])[C:25]2[CH:29]=[C:30]([CH2:33][NH:34][C:35]([C:37]([CH3:38])([CH3:40])[CH3:39])=[O:36])[CH:31]=[CH:32][C:24]=2[Cl:23])=[CH:13][N:12]=1

Participants

4

Reactant 2

HCID 584832082-Chloro-5-[(2,2-dimethylpropanamido)methyl]benzoic acidHCID 58483478HCID 58483478, compound

Product 1

HCID 86658672HCID 86658672, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to Example 2f from N-(4-bromophenyl)-2-(2,2-difluoroethyl)oxy-5-amino-nicotinic acid amide and 2-chloro-5-(tert-butylcarbonylamino)methyl-benzoic acid with PPA and TEA in THF. Purification via HPLC (Method A)

Workup

  1. customPurification via HPLC (Method A)

Sources & evidence

ORD record
ord-cfc3f754fde543af9841c834cf974eae
Source dataset
uspto-grants-2015_02
Patent number
US08951999B2

Reaction notes

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