Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → HCID 52919967, compound

HRID 1846106Notes

Reaction equation

HRID 1846106 reaction equation
[Cl:1][C:2]1[C:10]([CH2:11][NH:12][C:13]([C:15]([CH3:18])([CH3:17])[CH3:16])=[O:14])=[CH:9][CH:8]=[C:7]([F:19])[C:3]=1[C:4]([OH:6])=O.[NH2:20][C:21]1[CH:22]=[CH:23][C:24]([O:37][CH2:38][CH:39]([F:41])[F:40])=[C:25]([CH:36]=1)[C:26]([NH:28][C:29]1[CH:34]=[CH:33][C:32]([Br:35])=[CH:31][CH:30]=1)=[O:27].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>C1COCC1>[F:41][CH:39]([F:40])[CH2:38][O:37][C:24]1[CH:23]=[CH:22][C:21]([NH:20][C:4](=[O:6])[C:3]2[C:7]([F:19])=[CH:8][CH:9]=[C:10]([CH2:11][NH:12][C:13]([C:15]([CH3:18])([CH3:17])[CH3:16])=[O:14])[C:2]=2[Cl:1])=[CH:36][C:25]=1[C:26]([NH:28][C:29]1[CH:34]=[CH:33][C:32]([Br:35])=[CH:31][CH:30]=1)=[O:27]

Participants

5

Reactant 3

HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 58483224HCID 58483224, compoundHCID 58483373HCID 58483373, compound

Product 1

HCID 52919967HCID 52919967, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to 43b from 2-chloro-3-(tert-butylcarbonylamino-methyl)-6-fluoro-benzoic acid and 5-amino-N-(4-bromo-phenyl)-2-(2,2-difluoro-ethoxy)-benzamide with HATU and TEA in THF.

Sources & evidence

ORD record
ord-3fadcd2041fa461e88a3e767c2a2f972
Source dataset
uspto-grants-2015_02
Patent number
US08951999B2

Reaction notes

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