Di-tert-butyl dicarbonate → HCID 89964282, compound

HRID 1846234Notes

Reaction equation

HRID 1846234 reaction equation
[CH2:1]([N:4]([C:12]1[C:13](Br)=[N:14][CH:15]=[CH:16][CH:17]=1)[C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8])[CH:2]=C.C(NC1C(Br)=NC=CC=1)C=C.CC([O:34]C(OC(OC(C)(C)C)=O)=O)(C)C>C(Cl)Cl>[O:34]=[C:2]1[C:13]2=[N:14][CH:15]=[CH:16][CH:17]=[C:12]2[N:4]([C:5]([O:6][C:7]([CH3:8])([CH3:9])[CH3:10])=[O:11])[CH2:1]1

Participants

5

Reactant 3

HCID 90495Di-tert-butyl dicarbonateHCID 89964062HCID 89964062, compoundHCID 89964404HCID 89964404, compound

Product 1

HCID 89964282HCID 89964282, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-butyl allyl(2-bromopyridin-3-yl)carbamate. To a solution of N-allyl-2-bromopyridin-3-amine (1 eq.) and DCM (0.2 M) is added (Boc)2O (1.5 eq.). The solution is stirred at room temperature until judged complete by TLC. The solution is concentrated in vacuo and purified by column chromatography to give the title compound.

Workup

  1. concentrationThe solution is concentrated in vacuo
  2. custompurified by column chromatography

Sources & evidence

ORD record
ord-af0b2763c8034ad091406bc7813507cb
Source dataset
uspto-grants-2015_02
Patent number
US08952009B2

Reaction notes

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