反应详情

Methyl 6-(hydroxymethyl)nicotinate (1.0 g, 6.0 mmol), 2,3-dihydropyran (1.5 mL, 16.5 mmol), and p-TsOH (1.14 g, 6.0 mmol) were combined in CH2Cl2 (100 mL) and stirred at room temperature for 18 hours. An additional 1 mL of 2,3-dihyropyran was added and the reaction was continued at room temperature for 24 hours. The reaction mixture was washed with water (200 mL), dried (MgSO4), filtered, and concentrated, to afford methyl 6-((tetrahydro-2H-pyran-2-yloxy)methyl)nicotinate (1.5 g, quantitative).

1. waitthe reaction was continued at room temperature for 24 hours
2. washThe reaction mixture was washed with water (200 mL)
3. dry with materialdried (MgSO4)
4. filtrationfiltered
5. concentrationconcentrated