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HRID1846370

反应详情

EQUATION

反应方程式

HRID 1846370 的结构方程式

REACTANTS

反应物

2
结构：CN(C)C(OC(C)(C)C)N(C)C
HCID79885

tert-Butoxy bis(dimethylamino)methane

C9H22N2O

结构：Cc1cc(-c2nc3ccccc3c(=O)n2-c2ccc(Br)cc2)ccc1[N+](=O)[O-]
HCID86659822

未命名化合物

PRODUCTS

生成物

1
结构：CN(C)/C=C/c1cc(-c2nc3ccccc3c(=O)n2-c2ccc(Br)cc2)ccc1[N+](=O)[O-]
HCID86659823

未命名化合物

收率 95.4%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度
60 °C

PROCEDURE

实验过程

tert-Butoxybis(dimethylamino)methane (2.0 mL, 9.60 mmol) was added to a solution of 3-(4-bromophenyl)-2-(3-methyl-4-nitrophenyl)quinazolin-4(3H)-one (1.4 g, 3.20 mmol) in DMF (30 mL). Stirring at 60° C. for 2 hours and concentrating in vacuo afforded (E)-3-(4-bromophenyl)-2-(3-(2-(dimethylamino)vinyl)-4-nitrophenyl)quinazolin-4(3H)-one (1.5 g, quantitative).

WORKUP

后处理

  1. concentrationconcentrating in vacuo