HCID 66978206, compound → HCID 66978194, compound

HRID 1846430Notes

Reaction equation

HRID 1846430 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[NH:10][C:11](=O)[CH3:12]>C(O)(=O)C.Cl>[CH3:12][C:11]1[NH:1][C:2]2[CH:7]=[C:6]([NH2:8])[CH:5]=[C:4]([CH3:9])[C:3]=2[N:10]=1

Participants

4

Reactant 1

HCID 66978206HCID 66978206, compound

Product 1

HCID 66978194HCID 66978194, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolvent2×HCID 313Hydrochloric AcidSolvent2×

Procedure

33.0 g (0.184 mol) N-(2,4-diamino-6-methyl-phenyl)-acetamide were stirred in 400 mL glacial acetic acid for 1.5 h at 100° C. The glacial acetic acid was eliminated i.vac. and the residue remaining was triturated with ether, suction filtered and dried. The free base thus obtained was taken up in methanolic hydrochloric acid and left to stand. The hydrochloride slowly settling out as a precipitate was suction filtered, washed with acetone and dried.

Workup

  1. customand the residue remaining was triturated with ether, suction
  2. filtrationfiltered
  3. customdried
  4. customThe free base thus obtained
  5. waitleft
  6. filtrationfiltered
  7. washwashed with acetone
  8. customdried

Sources & evidence

ORD record
ord-1da32f0c931c4a809025f89e35a0392d
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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