反应详情

温度

50 °C

1.66 g (12.0 mmol) potassium carbonate were added to 0.922 g (6.00 mmol) 4,6-dichloropyrimidine and 1.11 g (6.60 mmol) 4-amino-3-methyl-5-nitro-phenol in 1.5 mL DMF and the mixture was stirred for 6 h at 50° C. Then the mixture was added to ice water and extracted several times with EtOAc. The combined organic phases were dried on sodium sulphate, evaporated down and purified by flash chromatography. The product-containing fractions were combined and evaporated down. The residue was triturated with EtOAc, suction filtered and dried under HV.

1. extractionextracted several times with EtOAc
2. customThe combined organic phases were dried on sodium sulphate
3. customevaporated down
4. custompurified by flash chromatography
5. customevaporated down
6. customThe residue was triturated with EtOAc, suction
7. filtrationfiltered
8. customdried under HV