反应详情

温度

60 °C

0.20 g (1.15 mmol) 6-hydroxy-4-methylbenzo[d]oxazol-2(3H)-one and 0.19 g (1.16 mmol) 2-amino-4,6-dichloropyrimidine in 3.0 mL DMF were combined with 0.22 g (1.59 mmol) potassium carbonate and stirred overnight at 60° C. Then water was added and the precipitate formed was suction filtered, washed and dried. The substance was purified by preparative HPLC-MS. The fractions containing product were combined and evaporated down i.vac.

1. customthe precipitate formed
2. filtrationfiltered
3. washwashed
4. customdried
5. customThe substance was purified by preparative HPLC-MS
6. additionThe fractions containing product
7. customevaporated down i.vac